Paraformaldehyde - PFA
Paraformaldehyde is a polymer form of formaldehyde. It can be used for the same applications as aqueous formaldehyde solutions. The main advantage of using Paraformaldehyde is that, it can be converted to varied concentrations of formaldehyde as per the requirement like higher concentration in the manufacture of resins with high solids content. It is mainly used to manufacture various types of resins such as amino resins (UF, MUF, MF resins), phenolic resins etc.
Chemanol produces two grades of Paraformaldehyde prills and powder with 96±1% purity.
Paraformaldehyde is a fixative commonly used in staining membrane-associated proteins. It chemically cross links free amino groups, preserving cellular architecture by establishing a network of interactions.
Paraformaldehyde 96% is an industrial chemical made with polymerization of formaldehyde. It is also known as Formaldehyde resin.
C2H62•
Paraformaldehyde 96 % is often used as a disinfectant. It is most certainly harmful to life, especially when it comes to chronic exposure.
Paraformaldehyde 96% is soluble in hot water (slightly in cold water) and alcohols..
It can be purchased in a solid form and diluted to prepare a 4% paraformaldehyde solution in PBS. This solution is most commonly used in research settings and can substitute 10% formalin.
You have to depolymerize paraformaldehyde to get it to "dissolve" and form a formaldehyde (really methylene hydrate) solution. The depolymerization is a reaction of the polymer with water: a hydrolysis. It needs hydroxide ions (OH-) as a catalyst, and also some heat to get the job done in reasonable time.
Paraformaldehyde is primarily used in biological and biomedical research for fixing cells and tissues. When dissolved in a buffer like PBS (phosphate-buffered saline) to make a 4% solution, its main function is to crosslink proteins within cells and tissues.
low future exposure can cause itching and a skin rash. ► Paraformaldehyde may cause an asthma-like allergy. Future exposure can cause asthma attacks with shortness of breath, wheezing, coughing, and/or chest tightness. ► Repeated high exposure may affect the kidneys.
The aqueous solution formalin is 37-40 percent formaldehyde in water or methanol. Paraformaldehyde is the crystallized polymer of formaldehyde (97%) that is weighed out and dissolved in solution for experimentation or for cell and tissue fixation.
Dissolve 32 g paraformaldehyde in 200 ml water. To help dissolution, add 0.34 g Na2CO3 to the PFA solution and stir until the solution is clear. Heat the solution on a hot plate until the paraformaldehyde is completely dissolved, but do not heat above 60°.
Paraformaldehyde is the informal name of polyoxymethylene, a polymer of formaldehyde (also known by many other and confusing names, such as 'paraform`, 'formagene`, 'para`, 'polyoxymethane`).
Identification. ALDER paraformaldehyde is a white solid low molecular weight polymer of formaldehyde available in the form of free flowing flakes. It contains 89-91% of formaldehyde and 9-11% of water.
This is used as a fixative for electron microscopy and in situ hybridization and has become popular as a general histologic fixative in laboratories that employ these techniques. The paraformaldehyde should be prepared in a buffered solution at pH 7 and refrigerated until use.
Paraformaldehyde is a white crystalline solid polymer with pungent odor and generates toxic formaldehyde gas when heated. It may react violently with strong oxidizing agents and less with bases. Paraformaldehyde is slightly soluble in alcohols and insoluble in ethers, hydrocarbons, and carbon tetrachloride.
